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学会発表・論文・特許等

学会・講演会・セミナー

2013-07-04
第29回日本DDS学会学術集会
(楠 理佐1,扇田 隆司1,坂井 美香1,板倉 祥子1,濱 進1,真島 英司2,小暮 健太朗1 ; 1京都薬大,2プロテノバ)
「膜貫通型Protein A再構成リポソームを基盤とした新規抗体修飾ナノキャリアの開発」
2013-03-27
日本薬学会第133年会
(坂井 美香1,濱 進1,板倉 祥子1,三橋 尚登2,土谷 博之1,真島 英司2,小暮 健太朗1 ; 1京都薬大,2プロテノバ)
「改良型プロテインAを介して抗体修飾可能な新規標的化ナノ粒子の開発」
2011-10-25
第244回液体クロマトグラフィー研究懇談会 (真島)
「HPLC による血中バイオマーカーの微量精製」
2011-03-28
日本薬学会第131年会
(大野 さゆみ1,濱 進1,三橋 尚登2,土谷 博之1,真島 英司2,小暮 健太朗1 ; 1京都薬大,2プロテノバ)
「Protein A-R28 を利用した抗体修飾ナノ粒子の開発」
2009-10-21
2009-04-20
17th全国クロマト学術報告会(中国) (真島)
「Application of High-Performance Liquid Chromatography for Discovery of Biomarkers in Proteomics」
2008-12-11
2008-03-28
2007-12-11
BMB2007 生化学会・分子生物学会合同大会 ランチョンセミナー (真島)
「病態プロテオミクス: バイオマーカー候補のナノグラム精製」
2007-08-29
バイオラッド ユーザーズミーティング (真島)
「ProteinChip SELDIシステムを用いたタンパク質精製・同定の実際」
2006-07-08
徳島大学講演会 (真島)
「Proteomics for Biomarker Discovery」
2006-02-02
東ソーTSK GEL 研究会 (真島)
「プロテオーム解析の現状と将来展望:微量タンパク質精製の実際」

新聞発表・雑誌記事など

2016-02-17
日経産業新聞に、新製品「Protein L-Agarose HC」を紹介する記事が掲載されました。
2016-02-16
日本経済新聞に、新製品「Protein L-Agarose HC」を紹介する記事が掲載されました。
2014-10-02
日刊工業新聞に当社を紹介する記事が掲載されました。
2013-10-17
2013年10月17日発行の「ビジネス香川」に当社の紹介記事が掲載されました。
2013-04-18
日経産業新聞に新製品「抗体トランスフェクション試薬 Ab-Carrier (エービーキャリア-)」を紹介する記事が掲載されました。

刊行物・論文(真島)

Susumu Hama, Mika Sakai, Shoko Itakura, Eiji Majima, Kentaro Kogure
Rapid modification of antibodies on the surface of liposomes composed of high-affinity protein A-conjugated phospholipid for selective drug delivery.
Biochem. Biophys. Reports, 2021, 27, 101067

1) S. Itakura, S. Hama, H. Ikeda, N. Mitsuhashi, E. Majima, and K. Kogure
Effective capture of proteins inside living cells by antibodies indirectly linked to a novel cell-penetrating polymer-modified protein A derivative.
 FEBS J., 2015; 282: 142-152.
 
2) 真島英司
「高結合アルカリ耐久型抗体精製アフィニティーゲル担体「Ab-Capcher ExTra」の開発」
 バイオインダストリー, 2012; (7): 66-71.

 
3) Y. Shinohara, M. Hashimoto, Y. Kihira, K. Ohkura, E. Majima, and H. Terada
Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier.
 Yakugaku Zasshi, 2010; 130(2): 199-204.

4) 真島英司、寺田 弘
 「等電点電気泳動」「アクリルアミドゲル電気泳動」タンパク質第1巻(関水和久,富田基郎編),廣川書店,2008, pp188-220.
 
5) A. Iwahashi, A. Ishii, N. Yamazaki, M. Hashimoto, K. Ohkura, M. Kataoka, E. Majima, H. Terada, and Y. Shinohara
Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier.
 Mitochondrion, 2008; 8(2): 196-204.
 
6) Y. Hatori, Eiji Majima, Takeo Tsuda, and Chikashi Toyoshima
Domain Organization and Movements in Heavy Metal Ion Pumps: PAPAIN DIGESTION OF CopA, A Cu+-TRANSPORTING ATPase.
 J. Biol. Chem., 2007; 282: 25213 - 25221.

 
7) A. Iwahashi, Y. Kihira, E. Majima, H. Terada, N. Yamazaki, M. Kataoka, and Y. Shinohara
The structure of the second cytosolic loop of the yeast mitochondrial ADP/ATP carrier AAC2 is dependent on the conformational state.
 Mitochondrion, 2006; 6(5): 245-51.

 
8) N. Katunuma, Q.T. Le, E. Murata, A. Matsui, E. Majima, N. Ishimaru, Y. Hayashi, and A. Ohashi
A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine.
 FEBS Lett, 2006; 580(15): 3699-705.

 
9) T. Ishida, M. Ichihara, X. Wang, K. Yamamoto, J. Kimura, E. Majima, and H. Kiwada
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
 J Control Release, 2006; 112(1): 15-25.

 
10) Y. Kihira, M. Hashimoto, Y. Shinohara, E. Majima, and H. Terada
Roles of Adjoining Asp and Cys Residues of First Matrix-Facing Loop in Transport Activity of Yeast and Bovine Mitochondrial ADP/ATP Carriers.
 J. Biochem., 2006; 139: 575 - 582.

 
11) Y. Kihira, E. Majima, Y. Shinohara, and H. Terada
Cysteine labeling studies detect conformational changes in region 106-132 of the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae.
 Biochemistry, 2005; 44(1): 184-92.

 
12) Y. Kihira, A. Iwahashi, E. Majima, H. Terada, and Y. Shinohara
Twisting of the second transmembrane alpha-helix of the mitochondrial ADP/ATP carrier during the transition between two carrier conformational states.
 Biochemistry, 2004; 43(48): 15204-9.

 
13) A. Ohashi, E. Murata, K. Yamamoto, E. Majima, E. Sano, Q.T. Le, and N. Katunuma
New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors.
 Biochem Biophys Res Commun, 2003; 306(1): 98-103.

 
14) N. Katunuma, A. Ohashi, E. Sano, E. Murata, H. Shiota, K. Yamamoto, E. Majima, and Q.T. Le
New cysteine protease inhibitors in physiological secretory fluids and their medical significance.
 Adv Enzyme Regul, 2003; 43: 393-410.

 
15) A. Tokumura, E. Majima, Y. Kariya, K. Tominaga, K. Kogure, K. Yasuda, and K. Fukuzawa
Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase.
 J. Biol. Chem., 2002; 277: 39436 - 39442.

 
16) S. Goto, H. Chuman, E. Majima, and H. Terada
How does the mitochondrial ADP/ATP carrier distinguish transportable ATP and ADP from untransportable AMP and GTP?Dynamic modeling of the recognition/translocation process in the major substrate binding region.
 Biochim Biophys Acta, 2002; 1589(2): 203-18.

 
17) E. Majima, M. Takeda, S. Miki, Y. Shinohara, and H. Terada
Close Location of the First Loop to the Third Loop of the Mitochondrial ADP/ATP Carrier Deduced from Cross-Linking Catalyzed by Copper-o-Phenanthroline of the Solubilized Carrier with Triton X-100.
 J. Biochem., 2002; 131: 461 - 468.

 
18) T. Hatanaka, Y. Kihira, Y. Shinohara, E. Majima, and H. Terada
Characterization of loops of the yeast mitochondrial ADP/ATP carrier facing the cytosol by site-directed mutagenesis.
 Biochem Biophys Res Commun, 2001; 286(5): 936-42.

 
19) 真島英司、寺田 弘
 「血清アルブミン」血漿タンパク質Ⅰ(長沢滋治編),廣川書店,2001, pp1-6.

 
20) T. Hatanaka, M. Hashimoto, E. Majima, Y. Shinohara, and H. Terada
Significant Effect of the N-terminal Region of the Mitochondrial ADP/ATP Carrier on Its Efficient Expression in Yeast Mitochondria.
 J. Biol. Chem., 2001; 276: 28881 - 28888.

 
21) T. Hatanaka, Y. Takemoto, M. Hashimoto, E. Majima, Y. Shinohara, and H. Terada
Significant expression of functional human type 1 mitochondrial ADP/ATP carrier in yeast mitochondria.
 Biol Pharm Bull, 2001; 24(6): 595-9.

 
22) E. Majima, M. Ishida, S. Miki, Y. Shinohara, and H. Terada
Specific Labeling of the Bovine Heart Mitochondrial Phosphate Carrier with Fluorescein 5-Isothiocyanate. ROLES OF LYS185 AND PUTATIVE ADENINE NUCLEOTIDE RECOGNITION SITE IN PHOSPHATE TRANSPORT.
 J. Biol. Chem., 2001; 276: 9792 - 9799.

 
23) M. Hashimoto, E. Majima, T. Hatanaka, Y. Shinohara, M. Onishi, S. Goto, and H. Terada
Irreversible Extrusion of the First Loop Facing the Matrix of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling the Cys56 Residue with the SH-Reagent Methyl Methanethiosulfonate.
 J. Biochem., 2000; 127: 443 - 449.

 
24) 真島英司
 「日本におけるバイオベンチャー:成功への道のり」,化学と生物 38, 2000, pp589-593.

 
25) 真島英司、寺田 弘
 「ミトコンドリアADP/ATP トランスポーター:ATP合成に不可欠なヌクレオチドの輸送機構」ポンプとトランスポーター(日本生物物理学会編),共立出版,2000, pp179-196.

 
26) M. Hashimoto, E. Majima, T. Hatanaka, Y. Shinohara, M. Onishi, S. Goto, and H. Terada
Irreversible extrusion of the first loop facing the matrix of the bovine heart mitochondrial ADP/ATP carrier by labeling the Cys56 residue with the SH-reagent methyl methanethiosulfonate.
 J. Biochem. 127; 2000: 443-449

 
27) 山本謙治、真島英司
 「微量タンパク質の一次構造解析と機能解析」,細胞 31 ,1999,pp530-534.

 
28) T. Hatanaka, M. Hashimoto, E. Majima, Y. Shinohara and H. Terada
Functional Expression of the tandem-repeated homodimer of the mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae.
 Biochem. Biophys. Res. Commun. 262; 1999: 726-730

 
29) M. Hashimoto, E. Majima, S. Goto, Y. Shinohara and H. Terada
Fluctuation of the first loop facing the matrix of the mitochondrial ADP/ATP carrier deduced from intermolecular cross-linking of Cys56 residues by bifunctional dimaleimides.
 Biochemistry 38; 1999: 1050-1056

 
30) 真島英司、寺田 弘
 総説「ATPはいかにして膜を透過するか:ループの協調的スウィングによるミトコンドリアADP/ATP キャリアーの機能発現」,生物物理 38,1998,pp245-249.

 
31) M. Hashimoto, Y. Shinohara, E. Majima, T. Hatanaka, N. Yamazaki and H. Terada
Expression of the bovine heart mitochondrial ADP/ATP carrier in yeast mitochondria: Signigicantly enhanced expression by replacement of the N-terminal region of the bovine carrier by the corresponding regions of the yeast.
 Biochim. Biophys. Acta 44694; 1998: 1-12

 
32) E. Majima, N. Yamaguchi, H. Chuman, Y. Shinohara, S. Goto and H. Terada
Binding of the fluorescein derivative eosin Y to the mitochondrial ADP/ATP carrier: characterization of the adenine nucleotide binding site and possible transport mechanism.
 Biochemistry 37; 1998: 424-432

 
33) H. Terada and E. Majima
Important role of loops in the transport activity of the mitochondrial ADP/ATP carrier.
 Prog. Colloid Polym. Sci. 106; 1997: 192-197

 
34) 水口 潤、川原和彦、水口 隆、川島 周、内藤秀宗、広畑 衛、斉藤 明、飯森 信、真島英司
 「蛋白透過型フィルター(EVAL-CH) を使用した mini HDF による補体 factor D 除去の試み」,腎と透析 43, 1997, 161-163.

 
35) K. Kogure, K. Yamamoto, E. Majima, Y. Shinohara, K. Yamashita and H. Terada
Alteration of enzyme function of the type II hexokinase C-terminal half on replacements of restricted regions by corresponding regions of glucokinase.
 J. Biol. Chem. 271; 1996: 15230-15236

 
36) E. Majima, Y. Shinohara and H. Terada
Specific binding of the stilbene derivatives to the mitochondrial ADP/ATP carrier.
 Prog. Biophys. Mol. Biol. 65-S1; 1996: 134

 
37) E. Majima, K. Ikawa, M. Takeda, M. Hashimoto, Y. Shinohara and H. Terada
Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline.
 J. Biol. Chem. 270; 1995: 29548-29554

 
38) E. Majima, S. Goto, H. Hori, Y. Shinohara, Y.-M. Hong and H. Terada
Stabilities of the fluorescent SH-reagent eosin-5-maleimide and its adducts with sulfhydryl compounds.
 Biochem. Biophys. Acta 1243; 1995: 336-342

 
39) E. Majima, Y. Shinohara, N. Yamaguchi, Y.-M. Hong and H. Terada
Importance of loops of mitochondrial ADP/ATP carrier for its transport activity deduced from reactivities of its cysteine residues with the sulfhydryl reagent eosin-5-maleimide.
 Biochemistry 33; 1994: 9530-9536

 
40) E. Majima, H. Koike, Y.-M. Hong, Y. Shinohara and H. Terada
Characterization of cysteine residues of mitochondrial ADP/ATP carrier with SH-reagents eosin-5-maleimide and N-ethylmaleimide.
 J. Biol. Chem. 268; 1993: 22181-22187

 
41) 真島英司、寺田 弘
 「ADP/ATP 交換輸送」新生化学実験講座6「生体膜と膜輸送 下」(日本生化学会編),東京化学同人,1992, pp570-576.

 
42) E. Majima, M. Abe, and S. Higashi
Varying electrophoretic mobility of an esterase caused by a factor in extracts of Bacillus stearothermophilus cells.
 Can. J. Microbiol. 28; 1982: 1355-1364

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   日本 (4179517)、欧州 (1992692)、米国 (8674073)
2)「イムノグロブリン結合ドメイン多量体」
    日本 (6456831)、欧州 (14842570.5)、米国 (10208094)
3)「イムノグロブリン結合ポリペプチド」
    日本 (6950957)、欧州、米国 (11208441) 

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