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学会発表・論文等

学会・講演会・セミナー

2013-07-04
第29回日本DDS学会学術集会
(楠 理佐1,扇田 隆司1,坂井 美香1,板倉 祥子1,濱 進1,真島 英司2,小暮 健太朗1 ; 1京都薬大,2プロテノバ)
「膜貫通型Protein A再構成リポソームを基盤とした新規抗体修飾ナノキャリアの開発」
2013-03-27
日本薬学会第133年会
(坂井 美香1,濱 進1,板倉 祥子1,三橋 尚登2,土谷 博之1,真島 英司2,小暮 健太朗1 ; 1京都薬大,2プロテノバ)
「改良型プロテインAを介して抗体修飾可能な新規標的化ナノ粒子の開発」
2011-10-25
第244回液体クロマトグラフィー研究懇談会 (真島)
「HPLC による血中バイオマーカーの微量精製」
2011-03-28
日本薬学会第131年会
(大野 さゆみ1,濱 進1,三橋 尚登2,土谷 博之1,真島 英司2,小暮 健太朗1 ; 1京都薬大,2プロテノバ)
「Protein A-R28 を利用した抗体修飾ナノ粒子の開発」
2009-10-21
2009-04-20
17th全国クロマト学術報告会(中国) (真島)
「Application of High-Performance Liquid Chromatography for Discovery of Biomarkers in Proteomics」
2008-12-11
2008-03-28
2007-12-11
BMB2007 生化学会・分子生物学会合同大会 ランチョンセミナー (真島)
「病態プロテオミクス: バイオマーカー候補のナノグラム精製」
2007-08-29
バイオラッド ユーザーズミーティング (真島)
「ProteinChip SELDIシステムを用いたタンパク質精製・同定の実際」
2006-07-08
徳島大学講演会 (真島)
「Proteomics for Biomarker Discovery」
2006-02-02
東ソーTSK GEL 研究会 (真島)
「プロテオーム解析の現状と将来展望:微量タンパク質精製の実際」

新聞発表・雑誌記事など

  2016-02-17
日経産業新聞に、新製品「Protein L-Agarose HC」を紹介する記事が掲載されました。
  2016-02-16
日本経済新聞に、新製品「Protein L-Agarose HC」を紹介する記事が掲載されました。
  2014-10-02
日刊工業新聞にプロテノバを紹介する記事が掲載されました。
  2013-10-17
2013年10月17日発行の「ビジネス香川」にプロテノバの紹介記事が掲載されました。
  2013-04-18
日経産業新聞に新製品「抗体トランスフェクション試薬 Ab-Carrier (エービーキャリア-)」を紹介する記事が掲載されました

刊行物・論文(真島)

1) S. Itakura, S. Hama, H. Ikeda, N. Mitsuhashi, E. Majima, and K. Kogure
Effective capture of proteins inside living cells by antibodies indirectly linked to a novel cell-penetrating polymer-modified protein A derivative.
FEBS J., 2015; 282: 142-152.
 
2) 真島英司
「高結合アルカリ耐久型抗体精製アフィニティーゲル担体「Ab-Capcher ExTra」の開発」
バイオインダストリー, 2012; (7): 66-71.
 
3) Y. Shinohara, M. Hashimoto, Y. Kihira, K. Ohkura, E. Majima, and H. Terada
Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier.
Yakugaku Zasshi, 2010; 130(2): 199-204.
 
4) 真島英司、寺田 弘
「等電点電気泳動」「アクリルアミドゲル電気泳動」タンパク質第1巻(関水和久,富田基郎編),廣川書店,2008, pp188-220.
 
5) A. Iwahashi, A. Ishii, N. Yamazaki, M. Hashimoto, K. Ohkura, M. Kataoka, E. Majima, H. Terada, and Y. Shinohara
Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier.
Mitochondrion, 2008; 8(2): 196-204.
 
6) Y. Hatori, Eiji Majima, Takeo Tsuda, and Chikashi Toyoshima
Domain Organization and Movements in Heavy Metal Ion Pumps: PAPAIN DIGESTION OF CopA, A Cu+-TRANSPORTING ATPase.
J. Biol. Chem., 2007; 282: 25213 - 25221.
 
7) A. Iwahashi, Y. Kihira, E. Majima, H. Terada, N. Yamazaki, M. Kataoka, and Y. Shinohara
The structure of the second cytosolic loop of the yeast mitochondrial ADP/ATP carrier AAC2 is dependent on the conformational state.
Mitochondrion, 2006; 6(5): 245-51.
 
8) N. Katunuma, Q.T. Le, E. Murata, A. Matsui, E. Majima, N. Ishimaru, Y. Hayashi, and A. Ohashi
A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine.
FEBS Lett, 2006; 580(15): 3699-705.
 
9) T. Ishida, M. Ichihara, X. Wang, K. Yamamoto, J. Kimura, E. Majima, and H. Kiwada
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
J Control Release, 2006; 112(1): 15-25.
 
10) Y. Kihira, M. Hashimoto, Y. Shinohara, E. Majima, and H. Terada
Roles of Adjoining Asp and Cys Residues of First Matrix-Facing Loop in Transport Activity of Yeast and Bovine Mitochondrial ADP/ATP Carriers.
J. Biochem., 2006; 139: 575 - 582. 
 
11) Y. Kihira, E. Majima, Y. Shinohara, and H. Terada
Cysteine labeling studies detect conformational changes in region 106-132 of the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae.
Biochemistry, 2005; 44(1): 184-92.
 
12) Y. Kihira, A. Iwahashi, E. Majima, H. Terada, and Y. Shinohara
Twisting of the second transmembrane alpha-helix of the mitochondrial ADP/ATP carrier during the transition between two carrier conformational states.
Biochemistry, 2004; 43(48): 15204-9.
 
13) A. Ohashi, E. Murata, K. Yamamoto, E. Majima, E. Sano, Q.T. Le, and N. Katunuma
New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors.
Biochem Biophys Res Commun, 2003; 306(1): 98-103.
 
14) N. Katunuma, A. Ohashi, E. Sano, E. Murata, H. Shiota, K. Yamamoto, E. Majima, and Q.T. Le
New cysteine protease inhibitors in physiological secretory fluids and their medical significance.
Adv Enzyme Regul, 2003; 43: 393-410.
 
15) A. Tokumura, E. Majima, Y. Kariya, K. Tominaga, K. Kogure, K. Yasuda, and K. Fukuzawa
Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase.
J. Biol. Chem., 2002; 277: 39436 - 39442.
 
16) S. Goto, H. Chuman, E. Majima, and H. Terada
How does the mitochondrial ADP/ATP carrier distinguish transportable ATP and ADP from untransportable AMP and GTP?Dynamic modeling of the recognition/translocation process in the major substrate binding region.
Biochim Biophys Acta, 2002; 1589(2): 203-18.
 
17) E. Majima, M. Takeda, S. Miki, Y. Shinohara, and H. Terada
Close Location of the First Loop to the Third Loop of the Mitochondrial ADP/ATP Carrier Deduced from Cross-Linking Catalyzed by Copper-o-Phenanthroline of the Solubilized Carrier with Triton X-100.
J. Biochem., 2002; 131: 461 - 468.
 
18) T. Hatanaka, Y. Kihira, Y. Shinohara, E. Majima, and H. Terada
Characterization of loops of the yeast mitochondrial ADP/ATP carrier facing the cytosol by site-directed mutagenesis.
Biochem Biophys Res Commun, 2001; 286(5): 936-42.
 
19) 真島英司、寺田 弘
「血清アルブミン」血漿タンパク質Ⅰ(長沢滋治編),廣川書店,2001, pp1-6.
 
20) T. Hatanaka, M. Hashimoto, E. Majima, Y. Shinohara, and H. Terada
Significant Effect of the N-terminal Region of the Mitochondrial ADP/ATP Carrier on Its Efficient Expression in Yeast Mitochondria.
J. Biol. Chem., 2001; 276: 28881 - 28888.
 
21) T. Hatanaka, Y. Takemoto, M. Hashimoto, E. Majima, Y. Shinohara, and H. Terada
Significant expression of functional human type 1 mitochondrial ADP/ATP carrier in yeast mitochondria.
Biol Pharm Bull, 2001; 24(6): 595-9.
 
22) E. Majima, M. Ishida, S. Miki, Y. Shinohara, and H. Terada
Specific Labeling of the Bovine Heart Mitochondrial Phosphate Carrier with Fluorescein 5-Isothiocyanate. ROLES OF LYS185 AND PUTATIVE ADENINE NUCLEOTIDE RECOGNITION SITE IN PHOSPHATE TRANSPORT.
J. Biol. Chem., 2001; 276: 9792 - 9799.
 
23) M. Hashimoto, E. Majima, T. Hatanaka, Y. Shinohara, M. Onishi, S. Goto, and H. Terada
Irreversible Extrusion of the First Loop Facing the Matrix of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling the Cys56 Residue with the SH-Reagent Methyl Methanethiosulfonate.
J. Biochem., 2000; 127: 443 - 449.
 
24) 真島英司
「日本におけるバイオベンチャー:成功への道のり」,化学と生物 38, 2000, pp589-593.
 
25) 真島英司、寺田 弘
「ミトコンドリアADP/ATP トランスポーター:ATP合成に不可欠なヌクレオチドの輸送機構」ポンプとトランスポーター(日本生物物理学会編),共立出版,2000, pp179-196.
 
26) M. Hashimoto, E. Majima, T. Hatanaka, Y. Shinohara, M. Onishi, S. Goto, and H. Terada
Irreversible extrusion of the first loop facing the matrix of the bovine heart mitochondrial ADP/ATP carrier by labeling the Cys56 residue with the SH-reagent methyl methanethiosulfonate.
J. Biochem. 127; 2000: 443-449
 
27) 山本謙治、真島英司
「微量タンパク質の一次構造解析と機能解析」,細胞 31 ,1999,pp530-534.
 
28) T. Hatanaka, M. Hashimoto, E. Majima, Y. Shinohara and H. Terada
Functional Expression of the tandem-repeated homodimer of the mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae.
Biochem. Biophys. Res. Commun. 262; 1999: 726-730
 
29) M. Hashimoto, E. Majima, S. Goto, Y. Shinohara and H. Terada
Fluctuation of the first loop facing the matrix of the mitochondrial ADP/ATP carrier deduced from intermolecular cross-linking of Cys56 residues by bifunctional dimaleimides.
Biochemistry 38; 1999: 1050-1056
 
30) 真島英司、寺田 弘
総説「ATPはいかにして膜を透過するか:ループの協調的スウィングによるミトコンドリアADP/ATP キャリアーの機能発現」,生物物理 38,1998,pp245-249.
 
31) M. Hashimoto, Y. Shinohara, E. Majima, T. Hatanaka, N. Yamazaki and H. Terada
Expression of the bovine heart mitochondrial ADP/ATP carrier in yeast mitochondria: Signigicantly enhanced expression by replacement of the N-terminal region of the bovine carrier by the corresponding regions of the yeast.
Biochim. Biophys. Acta 44694; 1998: 1-12
 
32) E. Majima, N. Yamaguchi, H. Chuman, Y. Shinohara, S. Goto and H. Terada
Binding of the fluorescein derivative eosin Y to the mitochondrial ADP/ATP carrier: characterization of the adenine nucleotide binding site and possible transport mechanism.
Biochemistry 37; 1998: 424-432
 
33) H. Terada and E. Majima
Important role of loops in the transport activity of the mitochondrial ADP/ATP carrier.
Prog. Colloid Polym. Sci. 106; 1997: 192-197
 
34) 水口 潤、川原和彦、水口 隆、川島 周、内藤秀宗、広畑 衛、斉藤 明、飯森 信、真島英司
「蛋白透過型フィルター(EVAL-CH) を使用した mini HDF による補体 factor D 除去の試み」,腎と透析 43, 1997, 161-163.
 
35) K. Kogure, K. Yamamoto, E. Majima, Y. Shinohara, K. Yamashita and H. Terada
Alteration of enzyme function of the type II hexokinase C-terminal half on replacements of restricted regions by corresponding regions of glucokinase.
J. Biol. Chem. 271; 1996: 15230-15236
 
36) E. Majima, Y. Shinohara and H. Terada
Specific binding of the stilbene derivatives to the mitochondrial ADP/ATP carrier.
Prog. Biophys. Mol. Biol. 65-S1; 1996: 134
 
37) E. Majima, K. Ikawa, M. Takeda, M. Hashimoto, Y. Shinohara and H. Terada
Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline.
J. Biol. Chem. 270; 1995: 29548-29554
 
38) E. Majima, S. Goto, H. Hori, Y. Shinohara, Y.-M. Hong and H. Terada
Stabilities of the fluorescent SH-reagent eosin-5-maleimide and its adducts with sulfhydryl compounds.
Biochem. Biophys. Acta 1243; 1995: 336-342
 
39) E. Majima, Y. Shinohara, N. Yamaguchi, Y.-M. Hong and H. Terada
Importance of loops of mitochondrial ADP/ATP carrier for its transport activity deduced from reactivities of its cysteine residues with the sulfhydryl reagent eosin-5-maleimide.
Biochemistry 33; 1994: 9530-9536
 
40) E. Majima, H. Koike, Y.-M. Hong, Y. Shinohara and H. Terada
Characterization of cysteine residues of mitochondrial ADP/ATP carrier with SH-reagents eosin-5-maleimide and N-ethylmaleimide.
J. Biol. Chem. 268; 1993: 22181-22187
 
41) 真島英司、寺田 弘
「ADP/ATP 交換輸送」新生化学実験講座6「生体膜と膜輸送 下」(日本生化学会編),東京化学同人,1992, pp570-576.
 
42) E. Majima, M. Abe, and S. Higashi
Varying electrophoretic mobility of an esterase caused by a factor in extracts of Bacillus stearothermophilus cells.
Can. J. Microbiol. 28; 1982: 1355-1364
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